NUCLEOTIDES IN MEDICINE AND SPORT
“HEALTH AND NUTRITION TODAY”
“HEALTH AND NUTRITION TODAY”
- Robert Pastore Hosts Mark Connell
Originally Broadcast Live on January 21, 2007
on WWRL am 1600 in New York City
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
Robert Pastore: Hello everybody and welcome to “Health and Nutrition Today”. I’m
your host Dr Robert Pastore and as I mentioned last week, I’m going to have this great
guest on. Well, I actually do. So let’s talk a little bit about who he is and then he’ll be
talking live, because guess what, Mark Connell the Founder and President of Nu Science
Labs, Inc. is live in the studio, not on the phone, but sitting directly across from me in the
studio. I’m so happy to have him with us. He is a brilliant man, who is going to help us talk
about one of my favorite new supplements, which is nuBound.
Now, you all know that I’m very difficult to please with specific supplements in nutrition. I’m
a big believer in Propax. I like specific brands and I have actually really started to adore
nuBound in my clinical practice. I’m using it for peri-surgical reasons, and we’ll discuss
that more in the program.
But Mark Connell, the President and Founder of Nu Science Labs is going to talk to us
about the science behind nuBound and its applications in sport.
For example, they’ve got a great tag line in their pamphlet, it says: Recover Faster, Train
Harder, Perform Better
So ladies and gentlemen, I introduce to you Mark Connell. Welcome Mark.
Mark Connell: Robert thank you very much. It’s a real pleasure to be here
in New York and in the studio today.
RP: Thank you Mark. It’s a pleasure to have you here. Please tell us a little bit about
the story behind nuBound.
MC: Sure, absolutely The story of nuBound begins not in the US, but over in
Asia. I’ve worked with an Asian-based pharmaceutical manufacturer for the last
dozen years. A number of infectious diseases have come up in Asia over the
last several years including bird flu, SARS and a number of infectious diseases
like the annual new strains of flu. So we got together and decided to look for a
nutritional supplement that could boost the immune system of our customers.
That’s something that everyone in Asia needs.
With that goal, I began a search the world over looking for promising
supplements. At the end of the search I had identified a manufacturer in Europe
who produced a very interesting product—one that forms the core of nuBound—
that was based upon nucleotides, the building blocks of DNA and RNA. This
product showed great promise for boosting the immune system. So we picked
the product up for Asia.
And in the course of my due diligence I had noted something more in the
research—that the product also showed great benefit for boosting the recovery
of athletes. Not only was it good for the immune system, it would also help
athletes in their recovery after exercise.
RP: Absolutely, and I believe that there was a clinical study that you found after you
had identified this active ingredient. Can you tell us about this please?
MC: Certainly, the study you mentioned was conducted by Dr. Lars
McNaughton, an exercise physiologist based at the University of Hull in
England. Dr. McNaughton completed his graduate studies at the University of
Oregon, a place with a great athletic heritage, and the home of Steve
Prefontaine and Alberto Salazar.
Lars McNaughton did a study looking at nucleotide supplementation by
endurance athletes. Briefly, the study tested athletes prior to and following
exercise to establish baseline values of two common indicators of exercise
stress—salivary immunoglobin and cortisol.
Then the subjects were given a nucleotide supplement (or a placebo) on a
double blind basis for 60 days, after which he brought them back in and tested
them again for the two indicators.
What McNaughton found were highly significant results for both increased
immune system response and faster recovery.
RP: That’s a critical aspect for an athlete. So they found a reduction in cortisol levels
in addition to an improvement in immune system response.
MC: Absolutely, as an athlete myself--I ran three marathons in 2006--
RP: How many people in our listening audience can say they ran three marathons? I’
m proud of you! Great job!
MC: Thanks--as an athlete, I looked at it and said here’s something I can use
in my own life. I started using the product and said, absolutely this is helping
me.
RP: And I want to make it clear to the listening audience that the active component
used in that study is the same ingredient used in nuBound.
MC: Yes, it’s an identical formulation.
RP: What’s funny is how Mark and I got together. Again, everybody who listens to the
show knows that I’m a tenacious researcher and that I’m always scouring the journals and
I found a study that looked at peri-surgical benefits from nucleotide supplementation.
And I get referred patients to me by many medical doctors throughout the US, and within
New York, some difficult cases, cases where a patient is getting ready for surgery and
they want me to do everything I can from a nutritional perspective, as a doctor of nutrition,
to address the patient’s health and their concerns. To get them ready to have their
surgeries heal appropriately and prevent infection. And I found this amazing published
paper on the immune enhancing effects and tissue restoring effect using nucleotide
supplementation.
So I did some research on nucleotide supplements and the best product I found with
regard to doses, safe doses that I can use, which Mark and I will discuss later, I found
nuBound.
I started using it in various cases – an ex-athlete prepping for surgery, an older person
who was never athletic for the last 25 years, but needed it for surgery. So, my end of the
spectrum was not originally from an athletic perspective.
Now I definitely am using it as part of my core program with athletes, absolutely core.
Right from the beginning when I see an athlete in my clinical practice, I think its important
that they start using nuBound.
I’ve found a tremendous increase in my own health using nuBound and I can vouch for
its ability to keep the immune system strong. I was also drawn to the research Mark was
presenting from a peri-surgical perspective.
Mark, by the way was trained as a biochemist and has worked in the pharmaceutical
industry for over a dozen years. I think, Mark, that biochemistry is our first language and
we could just go nuts talking about research for two hours, but I promise you we won’t do
that today.
Mark has looked at some of the exciting research that started on nucleotides… So Mark I’
ll turn it over to you.
MC: Thanks. The standard view in physiology was that the body produced its
own nucleotides and there was no need to add them in the diet. That for years
was the traditional view and nobody thought twice about dietary sources of
nucleotides.
What happened back about thirty years ago, was that a New York physician, a Dr.
Benjamin Franks, began to question this view. He said that this doesn’t always
seem to be the case. There are conditions where the body is under metabolic
stress or where the body is undergoing rapid growth where an exogenous,
dietary source of nucleotides could be beneficial to folks. He was one of the
first researchers to look into this issue.
What’s happened since he was doing his work in the early/mid 1970s is that
there has been a real explosion of research including several dozen studies
quantifying the benefits of dietary nucleotide supplementation for immune
system support in hospital patients.
One of the interesting clues was the finding that human mother’s milk has a high
level of nucleotides. That is one of the reasons mother’s milk is superior for
newborns, because the nucleotides help support the infant’s immune system.
RP: Absolutely. And it’s interesting that the Physician’s Desk Reference (PDR)
actually acknowledges this. There’s a section on nucleotides and nucleic acids in the
PDR and they show the mechanism of action of nucleotides has been demonstrated to
have an effect on a number of immune system functions and intestinal health.
When patients are under incredible stress the PDR says that there may be an increased
need for nucleotides. And supplementation may actually be the best way.
So if you’d like to talk to Mark or myself about nucleotides and clinical research or
anything in the field of clinical nutrition, please fell free to call us at 212-868-0975.
When Mark and I were talking about this show today, we wanted to make sure that we
gave the listening audience a great, well-rounded perspective with regard to nuBound
and nucleotides, how its used in clinical research and the beneficial outcomes.
We already covered how there’s this incredible stress reducing response. There’s a very
important immune system increase that’s critical, and there’s peer reviewed research to
back that up.
What’s also important to note is the dosing. Mark would you like to start our discussion
regarding dosing from the nucleotide perspective?
MC: Sure. What we did when we designed the nuBound supplement, was to
make sure that what we had was safe and that the dosages wouldn’t cause any
problems in the general public using this supplement without clinical
supervision.
And I’ll ask Robert to address later the types of problems that might arise from
taking larger doses on an unsupervised basis.
What we did was to create a product that with a four capsule per day dosage
provides about 115 mg of dietary nucleotides (ie, the four capsules we
recommend for normal consumption). I mentioned earlier Dr. Franks, who was a
pioneer in the field of nucleotide supplementation. This is the dosage he
recommended.
What we suggest is that athletes take four capsules per day as the normal
dosage. When an athlete is under particular stress, you can safely double that
dosage to eight capsules per day. An example of this stress might be when an
athlete is tapering their training prior to a big event and wants to make sure they
have fully recovered from the stresses/injuries during their training, or similarly,
following a marathon or other big event, when they need to recover.
RP: Absolutely. What Mark’s saying is based on clinical research. You can actually
increase the healing response and that’s key. You can also support the immune system.
If you’ve ever logged on to my web site, www.pastoreformulations.com, you know that I
wrote a paper regarding plant sterols and sterolins and how they modulate the immune
system.
And I cover a research paper on how marathoner runners, following a marathon actually
have a white blood cell count, specifically a T cell count, that can be equivalent to that of
an AIDS patient. They can have incredibly profound drops in their immune system
functioning and a product like nuBound seems to come to the rescue and help them. And
its based on clinical science.
Another very important thing with regard to dosing, and a reason I felt so comfortable with
nuBound, as opposed to other nucleic acid/nucleotide supplements, was the dosing.
How safe Mark was at choosing the correct dose. Because it gives me, as a doctor of
nutrition, wiggle room to use larger doses when I feel its warranted specifically for that
person, understanding that patient’s case, having the medical team and me work together
to get the right dosage for that patient. Where I will use very large quantities in certain
cases, and its not for the regular public to go off and do that. Its important that it’s
discussed with a professional in my field, to make sure they are using the right dose.
nuBound makes me feel happy and safe, because people can take the dose right off the
bottle and be very safe. In certain cases of uric acid increase or if you have gout, you
probably would not be wise to use a nucleic acid or nucleotide-based supplement, unless
again you are under the supervision of your doctor. You want to make sure to stay well
hydrated.
At the dosages used by Mark, it’s a very safe product. As a practitioner I’m so happy that
you put 120 capsules in a bottle because that makes my life easier. In peri-surgical
patients I use very large doses of this product. But again, under my supervision, the
surgeon’s supervision, and the supervision of the primary care physician, so we’re really
watching and monitoring the patient. Because everybody who listens knows that I’m a real
stickler for these things.
So if you’d like to talk to Mark and myself about anything in the field of clinical nutrition as
well as nucleotide research, please feel free to call at 212-868-0975.
Mark lets cover a little more about the clinical research. Do you have other studies you’d
like to talk about?
MC: Sure I would, but first let me digress for a moment and return to your
mention of the Physician’s Desk Reference, the PDR, and talk about conditions
of metabolic stress or rapid growth, its now recognized that the body requires
nucleotides to meet its requirements.
RP: That’s actually an amazing point.
MC: It is. And when you think about an athlete in a training program, that’s
actually the definition of what they are doing. They are using exercise to put
their body under metabolic stress, and the reaction they are looking for from
that stress is rapid cell growth to build, repair and strengthen their muscles.
An athlete in training will alternate heavy days with light days to give the body a
chance to recover between the big training stresses. And this stress on the
body is precisely is what’s being talked about in the PDR. Rapid growth is where
you are repairing the micro-tears that exercise creates in your muscle.
RP: Which is required for the hypertrophy, for the muscle growth itself.
And its quite interesting how many athletes I see in clinical practice that are the most sick.
By sick I don’t mean chronic disease, I mean they’ll frequently come down with infections.
They’ll get more colds for example.
I have athlete that’s using nuBound, that was climbing a mountain. He’s a cyclist, a
runner, a swimmer and he was planning to climb a mountain.
He comes into my office and here’s what he says to me. He says Dr. Pastore I’m going to
be in an oxygen deprivation tank for four weeks, on and off, to train my body to deal with
the altitude. Can you please put together a program to help me handle the stress. We
worked out a good strategic plan, which included some specific dietary and supplement
changes that were critical. One of the biggest things was using nuBound to make sure
we were repairing the tissue damage fast enough and making sure we were enhancing
the immune system.
This patient had first came to me a year prior with chronic upper respiratory tract
infections. He could not understand them. He said, I’m so healthy, look at my body fat,
look at how healthy I am. I told him that the problem was the constant metabolic stress
that needed to be addressed. And I’m so glad you’re bringing that up. That’s such a key
component.
And again its recognized in the peer-reviewed literature and recognized in the Physician’s
Desk Reference that it’s an acceptable utilization for nucleotides. Then there’s the
hypothesis, and that’s what current research is showing, that maybe we have a higher
dietary requirement when we are in an exercise state.
How can we compare the breast feeding in the infant to the intense athlete? Well, they’re
both in rapid cellular growth, and in the athlete there’s also rapid cellular destruction. But
you have rapid cellular growth and utilization.
There’s a lot of conditions--listeners who are also patients, know that I am always talking
about metabolic stressors.
When I was first studying clinical nutrition, my professor showed the metabolic stress of
rheumatoid arthritis. And he would say that specifically. And then professor Glade would
say, the metabolic stress of cancer. That specific diseases were metabolic stressors, they
required a higher tissue turnover rate, utilization of amino acids, hyperactivity of the
mitochondria and a greater need for nucleotides than other conditions. Than other
sedentary conditions.
So its very important, and I’m glad you brought that issue up, we get that message out to
those who are listening. Stress is a critical point and thank you for bringing us back to the
Physician’s Desk Reference.
MC: Absolutely. Let me talk about the natural sources of nucleotides.
People think, nucleotides, I’ve never heard of them before. What are they, they
sound dangerous.
Nucleotides occur in all natural foods. Any fruits, vegetables, grains, meats or
fish. Any natural, unrefined food that has cells. Each cell has a nucleus and you
have nucleotides in them.
The difference is that most foods have a fairly low concentration of nucleotides.
nuBound has a specially formulated concentrate of nucleotides that is prepared
from a yeast extract. We take that and concentrate the nucleotides (and some
RNA, which is closely related). We take that, which is a powder and pack it into
capsules. These 120 capsules per bottle we talked about provide a one month
supply.
RP: I’m so glad you mentioned that nuBound comes from yeast. One point I need to
touch on is that I’m sure there’s a listener out there saying, oh my goodness there’s yeast
or it comes from yeast, oh no, I’m in trouble. Well if you’re a regular listener to my show
you know that my doctoral dissertation in clinical nutrition was on polysystemic candidiasis
with resulting dysbiosis, so I’m very familiar with the yeast species and nucleotide therapy
actually is a treatment for candidiasis, its actually used in treating infections. So there
wouldn’t be a sensitivity to yeast in this instance.
This is why you have to get to the research, and cut through the stuff that’s on Google
and Yahoo, and get right to the facts.
One part of my practice is when a patient comes in on a referral from a medical doctor to
get a clinical program to address peri-surgical issues. I give them a diet of foods rich in
nucleotides: seafoods, fish, sardines, beans, mushrooms and beef, as well as a
supplementation list and of course on my supplementation list is nuBound.
I want to make sure, because we have so much to cover that I know we’ll keep talking to
the end of the show. I want to make sure that people visit www.nubound.net to get more
of the information, particularly on the McNaughton exercise physiology study that showed
reduced production of cortisol and increase to your immune system. And if you’re an
athlete and training hard and eating right with nuBound, you can recover faster, train
harder and perform better.
I also want to mention that you can get nuBound directly from my office because I use it
in clinical practice. So please feel free to call 212-575-5155 to try some nuBound.
Mark lets get back to the research or some other points that you wanted to make.
MC: Absolutely, thanks Robert. What I did want to discuss was the
distinction, or rather the similarity between two of the benefits from nucleotide
supplementation. It helps the body recover faster and it boosts the immune
system. Those two points are the principal reasons for athletes to use
nuBound.
But, I was at the University of Connecticut last month meeting with Bill Kraemer,
a very famous researcher, well known in the field of strength and conditioning
and particularly well versed in the endocrinology of exercise.
He commented to me that these are not two distinct benefits, they are really two
sides of the same coin. He pointed out that a strong immune system is integrally
linked to recovery. Recovery and the immune response are the same thing by a
different name.
RP: That’s absolutely right and if the immune system is suppressed, recovery will not
occur. And athletes have to realize that if they don’t take care of themselves they are
living in what I call the cortisol zone.
Some athletes have such high cortisol. There’s this zone of cortisol, when you produce
so much cortisol which is a tissue breakdown hormone, it’s a catabolic hormone, so that
anything that’s safe and effective, that can lower cortisol, will also help facilitate healing
and help keep tissue preserved.
MC: Exactly, and that brings us back around to the nuBound motto: Recover
Faster, Train Harder, and Perform Better!
RP: I can definitely vouch for that. Because in clinical practice there is a term, feeble,
which refers not just to someone who is weak, but it’s a clinical term for someone in a poly-
diseased state, they’re more sedentary, they’ve had numerous surgeries or have a
surgery coming up, they’re getting along in years. And that recover faster part is exactly
what I’m actually seeing in my clinical practice from patients who’ve had knee surgeries, or
hernia operations or intestinal surgery recovering better when I employ the nucleotides
from nuBound.
And again, lets be really redundant, you don’t just go out and grab just any old nucleotide
supplement. It’s a specifically targeted dose. You want the specific nucleotide complex in
nuBound, nuBound’s proprietary PSB complex based on research.
And if you know me and trust me, you know that I only zone in on a compound that I
believe is going to be very safe for patients and also for general recommendations. So
other people can get in on it. Because one of the most common reactions I receive from
patients is hey, can I give this to my mom or to my sister. And if its something I think is
very safe for them to blindly recommend, I’ll say yes, but only at the dose that’s
recommended on the bottle. But not what I’m doing with you. A dose beyond what is
indicated on the bottle I would want to sit down with them or have a doctor sit down with
them.
And again, to harp on this, nuBound is very safe product that can be used exactly as
directed on the label. It’s a wonderful product.
I urge you to log onto www.nubound.net to learn more about nuBound. And also, please
call my practice at 212-575-5155 to learn more about nuBound and to get nuBound in
your life.
So let’s talk more about who is using nuBound? Who do you see actually using
nuBound?
MC: Sure, we’ve had great response across the sporting community,
including everyday folks like you and I, who exercise to keep healthy, all the way
to people who are famous and even legendary in the sporting world.
Dick Beardsley, who is the second fastest US-born marathoner of all time, has
been taking nuBound since the Boston Marathon last year. Dick’s most famous
race was the “Duel in the Sun” 1982 running of the Boston Marathon where he
and Alberto Salazar ran the entire 26.2 mile race stride-for-stride.
When Dick first accepted a sample from me he warned me not to get my hopes
up. He said people were always asking him to try things because he was a
famous guy. About a month later he called back and said that he really did like
nuBound and that he wanted to get some more because he was running 100
miles per week to train for Grandma’s Marathon. Dick ran three marathons last
year, and either won or placed in his age group in all of them.
Dick had turned 50 last spring and he said that with nuBound he was recovering
like he did when he was 25. He said, he knows that nuBound works because he’
s kept a training diary for the last 30 years and knows exactly how long it takes
him to recover after any training session.
RP: Wow, that’s fantastic. I’d like to say a special thanks to my dear friend Mark
Connell, the President and Founder of Nu Science Labs, Inc. We were talking today
about nuBound and the web site is www.nubound.net. Also, please feel free to call me,
Dr. Pastore for an appointment and to get a hold of some nuBound.
your host Dr Robert Pastore and as I mentioned last week, I’m going to have this great
guest on. Well, I actually do. So let’s talk a little bit about who he is and then he’ll be
talking live, because guess what, Mark Connell the Founder and President of Nu Science
Labs, Inc. is live in the studio, not on the phone, but sitting directly across from me in the
studio. I’m so happy to have him with us. He is a brilliant man, who is going to help us talk
about one of my favorite new supplements, which is nuBound.
Now, you all know that I’m very difficult to please with specific supplements in nutrition. I’m
a big believer in Propax. I like specific brands and I have actually really started to adore
nuBound in my clinical practice. I’m using it for peri-surgical reasons, and we’ll discuss
that more in the program.
But Mark Connell, the President and Founder of Nu Science Labs is going to talk to us
about the science behind nuBound and its applications in sport.
For example, they’ve got a great tag line in their pamphlet, it says: Recover Faster, Train
Harder, Perform Better
So ladies and gentlemen, I introduce to you Mark Connell. Welcome Mark.
Mark Connell: Robert thank you very much. It’s a real pleasure to be here
in New York and in the studio today.
RP: Thank you Mark. It’s a pleasure to have you here. Please tell us a little bit about
the story behind nuBound.
MC: Sure, absolutely The story of nuBound begins not in the US, but over in
Asia. I’ve worked with an Asian-based pharmaceutical manufacturer for the last
dozen years. A number of infectious diseases have come up in Asia over the
last several years including bird flu, SARS and a number of infectious diseases
like the annual new strains of flu. So we got together and decided to look for a
nutritional supplement that could boost the immune system of our customers.
That’s something that everyone in Asia needs.
With that goal, I began a search the world over looking for promising
supplements. At the end of the search I had identified a manufacturer in Europe
who produced a very interesting product—one that forms the core of nuBound—
that was based upon nucleotides, the building blocks of DNA and RNA. This
product showed great promise for boosting the immune system. So we picked
the product up for Asia.
And in the course of my due diligence I had noted something more in the
research—that the product also showed great benefit for boosting the recovery
of athletes. Not only was it good for the immune system, it would also help
athletes in their recovery after exercise.
RP: Absolutely, and I believe that there was a clinical study that you found after you
had identified this active ingredient. Can you tell us about this please?
MC: Certainly, the study you mentioned was conducted by Dr. Lars
McNaughton, an exercise physiologist based at the University of Hull in
England. Dr. McNaughton completed his graduate studies at the University of
Oregon, a place with a great athletic heritage, and the home of Steve
Prefontaine and Alberto Salazar.
Lars McNaughton did a study looking at nucleotide supplementation by
endurance athletes. Briefly, the study tested athletes prior to and following
exercise to establish baseline values of two common indicators of exercise
stress—salivary immunoglobin and cortisol.
Then the subjects were given a nucleotide supplement (or a placebo) on a
double blind basis for 60 days, after which he brought them back in and tested
them again for the two indicators.
What McNaughton found were highly significant results for both increased
immune system response and faster recovery.
RP: That’s a critical aspect for an athlete. So they found a reduction in cortisol levels
in addition to an improvement in immune system response.
MC: Absolutely, as an athlete myself--I ran three marathons in 2006--
RP: How many people in our listening audience can say they ran three marathons? I’
m proud of you! Great job!
MC: Thanks--as an athlete, I looked at it and said here’s something I can use
in my own life. I started using the product and said, absolutely this is helping
me.
RP: And I want to make it clear to the listening audience that the active component
used in that study is the same ingredient used in nuBound.
MC: Yes, it’s an identical formulation.
RP: What’s funny is how Mark and I got together. Again, everybody who listens to the
show knows that I’m a tenacious researcher and that I’m always scouring the journals and
I found a study that looked at peri-surgical benefits from nucleotide supplementation.
And I get referred patients to me by many medical doctors throughout the US, and within
New York, some difficult cases, cases where a patient is getting ready for surgery and
they want me to do everything I can from a nutritional perspective, as a doctor of nutrition,
to address the patient’s health and their concerns. To get them ready to have their
surgeries heal appropriately and prevent infection. And I found this amazing published
paper on the immune enhancing effects and tissue restoring effect using nucleotide
supplementation.
So I did some research on nucleotide supplements and the best product I found with
regard to doses, safe doses that I can use, which Mark and I will discuss later, I found
nuBound.
I started using it in various cases – an ex-athlete prepping for surgery, an older person
who was never athletic for the last 25 years, but needed it for surgery. So, my end of the
spectrum was not originally from an athletic perspective.
Now I definitely am using it as part of my core program with athletes, absolutely core.
Right from the beginning when I see an athlete in my clinical practice, I think its important
that they start using nuBound.
I’ve found a tremendous increase in my own health using nuBound and I can vouch for
its ability to keep the immune system strong. I was also drawn to the research Mark was
presenting from a peri-surgical perspective.
Mark, by the way was trained as a biochemist and has worked in the pharmaceutical
industry for over a dozen years. I think, Mark, that biochemistry is our first language and
we could just go nuts talking about research for two hours, but I promise you we won’t do
that today.
Mark has looked at some of the exciting research that started on nucleotides… So Mark I’
ll turn it over to you.
MC: Thanks. The standard view in physiology was that the body produced its
own nucleotides and there was no need to add them in the diet. That for years
was the traditional view and nobody thought twice about dietary sources of
nucleotides.
What happened back about thirty years ago, was that a New York physician, a Dr.
Benjamin Franks, began to question this view. He said that this doesn’t always
seem to be the case. There are conditions where the body is under metabolic
stress or where the body is undergoing rapid growth where an exogenous,
dietary source of nucleotides could be beneficial to folks. He was one of the
first researchers to look into this issue.
What’s happened since he was doing his work in the early/mid 1970s is that
there has been a real explosion of research including several dozen studies
quantifying the benefits of dietary nucleotide supplementation for immune
system support in hospital patients.
One of the interesting clues was the finding that human mother’s milk has a high
level of nucleotides. That is one of the reasons mother’s milk is superior for
newborns, because the nucleotides help support the infant’s immune system.
RP: Absolutely. And it’s interesting that the Physician’s Desk Reference (PDR)
actually acknowledges this. There’s a section on nucleotides and nucleic acids in the
PDR and they show the mechanism of action of nucleotides has been demonstrated to
have an effect on a number of immune system functions and intestinal health.
When patients are under incredible stress the PDR says that there may be an increased
need for nucleotides. And supplementation may actually be the best way.
So if you’d like to talk to Mark or myself about nucleotides and clinical research or
anything in the field of clinical nutrition, please fell free to call us at 212-868-0975.
When Mark and I were talking about this show today, we wanted to make sure that we
gave the listening audience a great, well-rounded perspective with regard to nuBound
and nucleotides, how its used in clinical research and the beneficial outcomes.
We already covered how there’s this incredible stress reducing response. There’s a very
important immune system increase that’s critical, and there’s peer reviewed research to
back that up.
What’s also important to note is the dosing. Mark would you like to start our discussion
regarding dosing from the nucleotide perspective?
MC: Sure. What we did when we designed the nuBound supplement, was to
make sure that what we had was safe and that the dosages wouldn’t cause any
problems in the general public using this supplement without clinical
supervision.
And I’ll ask Robert to address later the types of problems that might arise from
taking larger doses on an unsupervised basis.
What we did was to create a product that with a four capsule per day dosage
provides about 115 mg of dietary nucleotides (ie, the four capsules we
recommend for normal consumption). I mentioned earlier Dr. Franks, who was a
pioneer in the field of nucleotide supplementation. This is the dosage he
recommended.
What we suggest is that athletes take four capsules per day as the normal
dosage. When an athlete is under particular stress, you can safely double that
dosage to eight capsules per day. An example of this stress might be when an
athlete is tapering their training prior to a big event and wants to make sure they
have fully recovered from the stresses/injuries during their training, or similarly,
following a marathon or other big event, when they need to recover.
RP: Absolutely. What Mark’s saying is based on clinical research. You can actually
increase the healing response and that’s key. You can also support the immune system.
If you’ve ever logged on to my web site, www.pastoreformulations.com, you know that I
wrote a paper regarding plant sterols and sterolins and how they modulate the immune
system.
And I cover a research paper on how marathoner runners, following a marathon actually
have a white blood cell count, specifically a T cell count, that can be equivalent to that of
an AIDS patient. They can have incredibly profound drops in their immune system
functioning and a product like nuBound seems to come to the rescue and help them. And
its based on clinical science.
Another very important thing with regard to dosing, and a reason I felt so comfortable with
nuBound, as opposed to other nucleic acid/nucleotide supplements, was the dosing.
How safe Mark was at choosing the correct dose. Because it gives me, as a doctor of
nutrition, wiggle room to use larger doses when I feel its warranted specifically for that
person, understanding that patient’s case, having the medical team and me work together
to get the right dosage for that patient. Where I will use very large quantities in certain
cases, and its not for the regular public to go off and do that. Its important that it’s
discussed with a professional in my field, to make sure they are using the right dose.
nuBound makes me feel happy and safe, because people can take the dose right off the
bottle and be very safe. In certain cases of uric acid increase or if you have gout, you
probably would not be wise to use a nucleic acid or nucleotide-based supplement, unless
again you are under the supervision of your doctor. You want to make sure to stay well
hydrated.
At the dosages used by Mark, it’s a very safe product. As a practitioner I’m so happy that
you put 120 capsules in a bottle because that makes my life easier. In peri-surgical
patients I use very large doses of this product. But again, under my supervision, the
surgeon’s supervision, and the supervision of the primary care physician, so we’re really
watching and monitoring the patient. Because everybody who listens knows that I’m a real
stickler for these things.
So if you’d like to talk to Mark and myself about anything in the field of clinical nutrition as
well as nucleotide research, please feel free to call at 212-868-0975.
Mark lets cover a little more about the clinical research. Do you have other studies you’d
like to talk about?
MC: Sure I would, but first let me digress for a moment and return to your
mention of the Physician’s Desk Reference, the PDR, and talk about conditions
of metabolic stress or rapid growth, its now recognized that the body requires
nucleotides to meet its requirements.
RP: That’s actually an amazing point.
MC: It is. And when you think about an athlete in a training program, that’s
actually the definition of what they are doing. They are using exercise to put
their body under metabolic stress, and the reaction they are looking for from
that stress is rapid cell growth to build, repair and strengthen their muscles.
An athlete in training will alternate heavy days with light days to give the body a
chance to recover between the big training stresses. And this stress on the
body is precisely is what’s being talked about in the PDR. Rapid growth is where
you are repairing the micro-tears that exercise creates in your muscle.
RP: Which is required for the hypertrophy, for the muscle growth itself.
And its quite interesting how many athletes I see in clinical practice that are the most sick.
By sick I don’t mean chronic disease, I mean they’ll frequently come down with infections.
They’ll get more colds for example.
I have athlete that’s using nuBound, that was climbing a mountain. He’s a cyclist, a
runner, a swimmer and he was planning to climb a mountain.
He comes into my office and here’s what he says to me. He says Dr. Pastore I’m going to
be in an oxygen deprivation tank for four weeks, on and off, to train my body to deal with
the altitude. Can you please put together a program to help me handle the stress. We
worked out a good strategic plan, which included some specific dietary and supplement
changes that were critical. One of the biggest things was using nuBound to make sure
we were repairing the tissue damage fast enough and making sure we were enhancing
the immune system.
This patient had first came to me a year prior with chronic upper respiratory tract
infections. He could not understand them. He said, I’m so healthy, look at my body fat,
look at how healthy I am. I told him that the problem was the constant metabolic stress
that needed to be addressed. And I’m so glad you’re bringing that up. That’s such a key
component.
And again its recognized in the peer-reviewed literature and recognized in the Physician’s
Desk Reference that it’s an acceptable utilization for nucleotides. Then there’s the
hypothesis, and that’s what current research is showing, that maybe we have a higher
dietary requirement when we are in an exercise state.
How can we compare the breast feeding in the infant to the intense athlete? Well, they’re
both in rapid cellular growth, and in the athlete there’s also rapid cellular destruction. But
you have rapid cellular growth and utilization.
There’s a lot of conditions--listeners who are also patients, know that I am always talking
about metabolic stressors.
When I was first studying clinical nutrition, my professor showed the metabolic stress of
rheumatoid arthritis. And he would say that specifically. And then professor Glade would
say, the metabolic stress of cancer. That specific diseases were metabolic stressors, they
required a higher tissue turnover rate, utilization of amino acids, hyperactivity of the
mitochondria and a greater need for nucleotides than other conditions. Than other
sedentary conditions.
So its very important, and I’m glad you brought that issue up, we get that message out to
those who are listening. Stress is a critical point and thank you for bringing us back to the
Physician’s Desk Reference.
MC: Absolutely. Let me talk about the natural sources of nucleotides.
People think, nucleotides, I’ve never heard of them before. What are they, they
sound dangerous.
Nucleotides occur in all natural foods. Any fruits, vegetables, grains, meats or
fish. Any natural, unrefined food that has cells. Each cell has a nucleus and you
have nucleotides in them.
The difference is that most foods have a fairly low concentration of nucleotides.
nuBound has a specially formulated concentrate of nucleotides that is prepared
from a yeast extract. We take that and concentrate the nucleotides (and some
RNA, which is closely related). We take that, which is a powder and pack it into
capsules. These 120 capsules per bottle we talked about provide a one month
supply.
RP: I’m so glad you mentioned that nuBound comes from yeast. One point I need to
touch on is that I’m sure there’s a listener out there saying, oh my goodness there’s yeast
or it comes from yeast, oh no, I’m in trouble. Well if you’re a regular listener to my show
you know that my doctoral dissertation in clinical nutrition was on polysystemic candidiasis
with resulting dysbiosis, so I’m very familiar with the yeast species and nucleotide therapy
actually is a treatment for candidiasis, its actually used in treating infections. So there
wouldn’t be a sensitivity to yeast in this instance.
This is why you have to get to the research, and cut through the stuff that’s on Google
and Yahoo, and get right to the facts.
One part of my practice is when a patient comes in on a referral from a medical doctor to
get a clinical program to address peri-surgical issues. I give them a diet of foods rich in
nucleotides: seafoods, fish, sardines, beans, mushrooms and beef, as well as a
supplementation list and of course on my supplementation list is nuBound.
I want to make sure, because we have so much to cover that I know we’ll keep talking to
the end of the show. I want to make sure that people visit www.nubound.net to get more
of the information, particularly on the McNaughton exercise physiology study that showed
reduced production of cortisol and increase to your immune system. And if you’re an
athlete and training hard and eating right with nuBound, you can recover faster, train
harder and perform better.
I also want to mention that you can get nuBound directly from my office because I use it
in clinical practice. So please feel free to call 212-575-5155 to try some nuBound.
Mark lets get back to the research or some other points that you wanted to make.
MC: Absolutely, thanks Robert. What I did want to discuss was the
distinction, or rather the similarity between two of the benefits from nucleotide
supplementation. It helps the body recover faster and it boosts the immune
system. Those two points are the principal reasons for athletes to use
nuBound.
But, I was at the University of Connecticut last month meeting with Bill Kraemer,
a very famous researcher, well known in the field of strength and conditioning
and particularly well versed in the endocrinology of exercise.
He commented to me that these are not two distinct benefits, they are really two
sides of the same coin. He pointed out that a strong immune system is integrally
linked to recovery. Recovery and the immune response are the same thing by a
different name.
RP: That’s absolutely right and if the immune system is suppressed, recovery will not
occur. And athletes have to realize that if they don’t take care of themselves they are
living in what I call the cortisol zone.
Some athletes have such high cortisol. There’s this zone of cortisol, when you produce
so much cortisol which is a tissue breakdown hormone, it’s a catabolic hormone, so that
anything that’s safe and effective, that can lower cortisol, will also help facilitate healing
and help keep tissue preserved.
MC: Exactly, and that brings us back around to the nuBound motto: Recover
Faster, Train Harder, and Perform Better!
RP: I can definitely vouch for that. Because in clinical practice there is a term, feeble,
which refers not just to someone who is weak, but it’s a clinical term for someone in a poly-
diseased state, they’re more sedentary, they’ve had numerous surgeries or have a
surgery coming up, they’re getting along in years. And that recover faster part is exactly
what I’m actually seeing in my clinical practice from patients who’ve had knee surgeries, or
hernia operations or intestinal surgery recovering better when I employ the nucleotides
from nuBound.
And again, lets be really redundant, you don’t just go out and grab just any old nucleotide
supplement. It’s a specifically targeted dose. You want the specific nucleotide complex in
nuBound, nuBound’s proprietary PSB complex based on research.
And if you know me and trust me, you know that I only zone in on a compound that I
believe is going to be very safe for patients and also for general recommendations. So
other people can get in on it. Because one of the most common reactions I receive from
patients is hey, can I give this to my mom or to my sister. And if its something I think is
very safe for them to blindly recommend, I’ll say yes, but only at the dose that’s
recommended on the bottle. But not what I’m doing with you. A dose beyond what is
indicated on the bottle I would want to sit down with them or have a doctor sit down with
them.
And again, to harp on this, nuBound is very safe product that can be used exactly as
directed on the label. It’s a wonderful product.
I urge you to log onto www.nubound.net to learn more about nuBound. And also, please
call my practice at 212-575-5155 to learn more about nuBound and to get nuBound in
your life.
So let’s talk more about who is using nuBound? Who do you see actually using
nuBound?
MC: Sure, we’ve had great response across the sporting community,
including everyday folks like you and I, who exercise to keep healthy, all the way
to people who are famous and even legendary in the sporting world.
Dick Beardsley, who is the second fastest US-born marathoner of all time, has
been taking nuBound since the Boston Marathon last year. Dick’s most famous
race was the “Duel in the Sun” 1982 running of the Boston Marathon where he
and Alberto Salazar ran the entire 26.2 mile race stride-for-stride.
When Dick first accepted a sample from me he warned me not to get my hopes
up. He said people were always asking him to try things because he was a
famous guy. About a month later he called back and said that he really did like
nuBound and that he wanted to get some more because he was running 100
miles per week to train for Grandma’s Marathon. Dick ran three marathons last
year, and either won or placed in his age group in all of them.
Dick had turned 50 last spring and he said that with nuBound he was recovering
like he did when he was 25. He said, he knows that nuBound works because he’
s kept a training diary for the last 30 years and knows exactly how long it takes
him to recover after any training session.
RP: Wow, that’s fantastic. I’d like to say a special thanks to my dear friend Mark
Connell, the President and Founder of Nu Science Labs, Inc. We were talking today
about nuBound and the web site is www.nubound.net. Also, please feel free to call me,
Dr. Pastore for an appointment and to get a hold of some nuBound.
Dr. Robert Pastore has PhD’s in both human nutrition and biochemistry. Dr. Pastore maintains his
currency with new developments in the field through active participation in the American College for
Advancement in Medicine, the National Association of Nutritional Professionals and the American
College of Nutrition. He is a Certified Nutrition Specialist, as a result of having served an internship at the
Hospital for Joint Diseases in New York City, under the auspices of the Certification Board of Nutritional
Specialists.
Dr. Pastore hosts a popular weekly radio show, “Health and Nutrition Today” which originates in New
York and is heard around the country.
currency with new developments in the field through active participation in the American College for
Advancement in Medicine, the National Association of Nutritional Professionals and the American
College of Nutrition. He is a Certified Nutrition Specialist, as a result of having served an internship at the
Hospital for Joint Diseases in New York City, under the auspices of the Certification Board of Nutritional
Specialists.
Dr. Pastore hosts a popular weekly radio show, “Health and Nutrition Today” which originates in New
York and is heard around the country.
Dr. Pastore is a consulting nutritionist
in New York City, where he works with
many hospitals, surgeons and
primary care physicians to provide
nutritional advice as part of a patient
care team. He is one of the unusual
Ph.D. nutritionists who see patients in
clinical practice rather than doing
research. This allows him to approach
each case scientifically, and in doing
so he has been deemed by his health
care colleagues to be a “biochemical
detective”.
in New York City, where he works with
many hospitals, surgeons and
primary care physicians to provide
nutritional advice as part of a patient
care team. He is one of the unusual
Ph.D. nutritionists who see patients in
clinical practice rather than doing
research. This allows him to approach
each case scientifically, and in doing
so he has been deemed by his health
care colleagues to be a “biochemical
detective”.
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |